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Controlled Hypotension and Renal Injury During Septoplasty

NCT07662577 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 110

Last updated 2026-06-23

No results posted yet for this study

Summary

This prospective randomized single-blind study investigated the effects of two different mean arterial pressure (MAP) targets during controlled hypotension on renal injury in patients undergoing septoplasty. Participants were randomized to a low MAP target group (50-57 mmHg) or a higher MAP target group (58-65 mmHg). Renal injury was assessed using plasma neutrophil gelatinase-associated lipocalin (NGAL) levels measured at baseline, 6 hours, and 24 hours postoperatively.

Conditions

  • Hypotension During Surgery
  • NGAL
  • Kidney Injury

Interventions

PROCEDURE

Controlled Hypotension (MAP 50-57 mmHg)

Controlled hypotension was maintained intraoperatively with a target MAP range of 50-57 mmHg according to the study protocol.

PROCEDURE

Controlled Hypotension (MAP 58-65 mmHg)

Controlled hypotension was maintained intraoperatively with a target MAP range of 58-65 mmHg according to the study protocol.

Sponsors & Collaborators

  • Fatih Sultan Mehmet Training and Research Hospital

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-05-01
Primary Completion
2020-05-01
Completion
2020-08-01

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07662577 on ClinicalTrials.gov