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Noradrenaline Versus Glypressin for Prevention of Hypotension After Deflation of Tourniquet in Knee Arthroplasty

NCT05774067 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 135

Last updated 2023-11-22

No results posted yet for this study

Summary

Pneumatic tourniquet is usually used in orthopedic surgeries, as it helps to decrease operative bed bleeding, and thus, maintaining a clean and dry surgical field allowing easy and clear identification of the anatomical structures. Despite that advantage, after its deflation, there is a blood volume shift towards that ischemic area, which may decrease cardiac preload leading to hypotension

Conditions

  • Norepinephrine, Glypressin, Tourniquet Deflation
  • Hypotension

Interventions

DRUG

Saline

patient received normal saline 4ml/kg/hr with deflation of tourniquet

DRUG

Norepinephrine

patient received noradrenaline infusion at rate 0.1 mcg/kg/min. with deflation of tourniquet

DRUG

glypressin

patient receive glypressin infusion at rate 2 mcg/kg/hr.

Sponsors & Collaborators

  • Tanta University

    lead OTHER

Principal Investigators

  • reda sobhy, MD · tanta university, faculty of medicine

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
40 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-12-01
Primary Completion
2023-06-30
Completion
2023-07-30

Countries

  • Egypt

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05774067 on ClinicalTrials.gov