Precision Antithrombotic Therapy

Summary

The goal of this observational study is to systematically analyze the relationship between trough/peak concentrations of novel oral anticoagulants (NOACs) and antiplatelet drugs with clinical events, aiming to provide high-level evidence for therapeutic drug monitoring (TDM) and personalized dosing.The main questions it aims to answer are:

* What are the optimal preventive and therapeutic concentration ranges for different NOACs (rivaroxaban, apixaban, dabigatran, edoxaban) and antiplatelet drugs (aspirin, indobufen)?
* What are the key factors influencing the blood drug concentrations of NOACs and antiplatelet drugs (such as liver and kidney function, age, weight, concomitant medications)?
* How can we establish a model to predict blood drug concentrations of NOACs and antiplatelet drugs and their related clinical events? Participants will receive routine clinical care. During treatment, blood samples will be regularly collected to measure patients' blood drug concentrations (Ctrough and Cmax), and clinical responses and adverse events will be recorded.

Conditions

• Non-valvular Atrial Fibrillation (NVAF)
• Venous Thromboembolism (VTE)
• MI(Myocardial Infarction)
• Ischemic Stroke

Interventions

OTHER

Not applicable- observational study

not have

Sponsors & Collaborators

• Renji Hospital, School of Medicine, Shanghai Jiao Tong University.

  collaborator UNKNOWN

• Xiangtan County People's Hospital

  collaborator UNKNOWN

• Taoyuan County People's Hospital

  collaborator UNKNOWN

• Hengyang Central Hospital

  collaborator OTHER_GOV

• Second Affiliated Hospital of Shaoyang University

  collaborator UNKNOWN

• The First Affiliated Hospital of Nanhu University

  collaborator UNKNOWN

• Yongzhou Central Hospital

  collaborator UNKNOWN

• Shenzhen Second People's Hospital

  collaborator OTHER

• First Affiliated Hospital of Xinjiang Medical University

  collaborator OTHER

• The Second Affiliated Hospital of Hunan University of Traditional Chinese Medicine

  collaborator OTHER

• Changsha First Hospital

  collaborator UNKNOWN

• Xiangya Changde Hospital

  collaborator UNKNOWN

• Jinshan Hospital Affiliated to Fudan University

  collaborator UNKNOWN

• Changsha Central Hospital

  collaborator OTHER

• Hunan Provincial Rehabilitation Hospital

  collaborator OTHER

• Hunan Cancer Hospital

  collaborator OTHER

• The Second Affiliated Hospital of Nanhu University

  collaborator UNKNOWN

• Hunan Medical College General Hospital

  collaborator UNKNOWN

• Shanghai Minhang District Central Hospital

  collaborator UNKNOWN

• The Ninth People's Hospital of Shanghai Jiao Tong University School of Medicine

  collaborator UNKNOWN

• Fudan University Affiliated Shanghai Fifth People's Hospital Hospital

  collaborator UNKNOWN

• The First Affiliated Hospital of Shaoyang University of Science and Technology

  collaborator UNKNOWN

• Renji Hospital Pu Nan Branch, Affiliated to Shanghai Jiao Tong University School of Medicine

  collaborator UNKNOWN

• Hunan Provincial People's Hospital (The First Affiliated Hospital of Hunan Normal University)

  collaborator UNKNOWN

• Eastern Theater Command General Hospital

  collaborator UNKNOWN

• Hunan Aerospace Hospital

  collaborator UNKNOWN

• The First Affiliated Hospital of Naval Medical University

  collaborator UNKNOWN

• Xiangtan Central Hospital

  collaborator OTHER

• Fengxian District Central Hospital of Shanghai

  collaborator UNKNOWN

• Shanghai Yangpu District Shidong Hospital

  collaborator UNKNOWN

• The First Affiliated Hospital of Hunan University of Traditional Chinese Medicine

  collaborator OTHER

• Huashan Hospital

  collaborator OTHER

• Hunan Provincial Maternal and Child Health Care Hospital

  collaborator OTHER

• Yueyang Central Hospital

  collaborator OTHER

• The First Affiliated Hospital of Dalian Medical University

  collaborator OTHER

• Jining Medical College Affiliated Hospital

  collaborator UNKNOWN

• Shanghai East Hospital

  collaborator OTHER

• The Third Xiangya Hospital of Central South University

  lead OTHER

Eligibility

Min Age

8 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2026-05-01

Primary Completion

2027-12-31

Completion

2027-12-31

Countries

• China

Study Locations