Surgery Plus Postoperative Radiotherapy for T4 Sinonasal Adenoid Cystic Carcinoma: A Prospective Observational Study
NCT07652489 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 70
Last updated 2026-06-17
Summary
This observational study follows patients with T4 stage sinonasal adenoid cystic carcinoma (a rare cancer of the nasal cavity/sinuses) who receive standard treatment: surgery followed by postoperative radiotherapy. The main goal is to measure the 3-year progression-free survival rate (the percentage of patients alive without cancer growth or spread). We will also assess overall survival, recurrence, side effects, and quality of life. This multicenter, prospective study will provide much-needed real-world data to improve patient counseling and guide future research.
Conditions
- Adenoid Cystic Carcinoma
- Sinonasal Carcinoma
Interventions
- PROCEDURE
-
Surgery
Postoperative Radiotherapy
Sponsors & Collaborators
-
Eye & ENT Hospital of Fudan University
lead OTHER
Eligibility
- Min Age
- 18 Years
- Max Age
- 80 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2026-06-01
- Primary Completion
- 2031-06-01
- Completion
- 2031-06-01
Countries
- China
Study Locations
More Related Trials
-
Exploratory Clinical Study of Neoadjuvant Immunotherapy Combined With Chemotherapy in Malignant Melanoma of Nasal and Paranasal Mucosa
NCT07614828 ·Status: WITHDRAWN ·Phase: PHASE2
-
Single Arm Study of Induction Chemoradiotherapy Combined With Surgery in the Treatment of Locally Advanced SNMM
NCT05009446 ·Status: UNKNOWN ·Phase: EARLY_PHASE1
-
Retrospective Investigation of the Impacts of Prognosis for Nasopharyngeal Carcinoma Patients
NCT02604472 ·Status: COMPLETED
-
A Multicenter Randomized Controlled Clinical Study on the Treatment of T3N1M0 High Risk Nasopharyngeal Carcinoma With or Without Induction Chemotherapy Before Concurrent Radiotherapy and Chemotherapy
NCT05622474 ·Status: NOT_YET_RECRUITING ·Phase: NA
-
Transnasal Endoscopic Surgery Combined With Adjuvant Immunotherapy for Recurrent NPC
NCT05350891 ·Status: RECRUITING ·Phase: PHASE2
-
Phase Ⅱ Study of Neoadjuvant Chemotherapy Followed by Concurrent Chemoradiation for Stage ⅣAB Nasopharyngeal Carcinoma
NCT00816816 ·Status: UNKNOWN ·Phase: PHASE2
-
Study of Concurrent Chemotherapy and Radiotherapy for Stage II Nasopharyngeal Carcinoma
NCT00817258 ·Status: UNKNOWN ·Phase: PHASE2
-
Phase Ⅱ Study of Neoadjuvant Chemotherapy Followed by Concurrent Chemoradiation for Stage Ⅲ Nasopharyngeal Carcinoma
NCT00816855 ·Status: UNKNOWN ·Phase: PHASE2
-
A Phase III Study of Radiotherapy With or Without Adjuvant C/T in Advanced Stage Nasopharyngeal Carcinoma Patients
NCT00201344 ·Status: TERMINATED ·Phase: PHASE3
-
Retro-Auricular Single-Site Endoscopic to Papillary Thyroid Carcinoma
NCT05263141 ·Status: COMPLETED ·Phase: NA
-
Benefit of Adding Chemotherapy And/Or Modification of Radiotherapy Schedule for Advance Nasopharyngeal Carcinoma (T3-4N0-1M0)
NCT00563862 ·Status: TERMINATED ·Phase: NA
-
Induction Chemotherapy Followed by Concurrent Chemoradiotherapy for Nasopharyngeal Carcinoma (NPC)
NCT00817583 ·Status: UNKNOWN ·Phase: PHASE2
-
PD-1 Inhibitor Plus Chemotherapy Followed by Immediate Versus Salvage Locoregional Radiotherapy in De Novo Metastatic NPC
NCT07235319 ·Status: RECRUITING ·Phase: PHASE3
-
Induction Chemotherapy in Young Patients With Locoregionally Advanced Nasopharyngeal Carcinoma
NCT03020329 ·Status: UNKNOWN ·Phase: PHASE2
-
A Transoral Retropterygoid Approach to Resect Recurrent Nasopharyngeal Carcinoma
NCT05432219 ·Status: UNKNOWN ·Phase: NA
-
International Collaborative Study on AJCC/UICC TNM-10 for Nasopharyngeal Cancer
NCT07013461 ·Status: RECRUITING
-
Elimination of Adjuvant Chemotherapy for Selected Stage II and III Nasopharyngeal Carcinoma
NCT03175939 ·Status: COMPLETED ·Phase: PHASE2
-
Combining RT With Immunotherapy and Chemotherapy in Metastatic Nasopharyngeal Carcinoma
NCT05385926 ·Status: RECRUITING ·Phase: PHASE2
-
A Real-world Study of the Efficacy and Safety of PD-1 Inhibitors Combined With Chemoradiotherapy in Lung Metastatic Nasopharyngeal Carcinoma
NCT07062484 ·Status: NOT_YET_RECRUITING ·Phase: NA
-
Surgery Plus Reduced Target Chemoradiotherapy vs Surgery Plus Reduced Dose Chemoradiotherapy for Newly Diagnosed Operable Nasopharyngeal Carcinoma.
NCT06529562 ·Status: RECRUITING ·Phase: NA
-
Reducing Target Volumes in NPC Treated With Induction Chemotherapy Followed by Concurrent Chemoradiotherapy
NCT04384627 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE3
-
Induction Chemotherapy in Patients With Locoregionally Advanced Nasopharyngeal Carcinoma
NCT01245959 ·Status: UNKNOWN ·Phase: PHASE3
-
Comparison the Effects of Different Neoadjuvant Chemotherapy Regimen on Acute Toxicity, Tumor Response, and Survival in Patients With Advanced Nasopharyngeal Carcinoma
NCT02500940 ·Status: UNKNOWN ·Phase: PHASE3
-
Endoscopic Nasopharyngectomy for Newly Diagnosed Stage I Nasopharyngeal Carcinoma Patients
NCT03353467 ·Status: RECRUITING ·Phase: NA
-
Surgery Alone Verus Sugery Combined with Dose-reduced Radiotherapy for Newly Diagnosed Stage I Nasopharyngeal Carcinoma
NCT06688760 ·Status: RECRUITING ·Phase: NA