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Treadmill Aerobic Training and Quality of Life in Anemic Females

NCT07651098 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 60

Last updated 2026-06-16

No results posted yet for this study

Summary

This randomized controlled trial investigates the effects of an 8-week structured treadmill aerobic training program on physical fitness and health-related quality of life in young adult females diagnosed with mild-to-moderate iron deficiency anemia. Sixty participants are randomly allocated into two equal groups of thirty. Group A (Experimental) receives standard daily oral iron therapy combined with a supervised moderate-intensity treadmill exercise program 3 times per week (30-40 minutes at 60-70% maximum heart rate). Group B (Control) receives standard oral iron therapy with no structured exercise. The study primary outcome measures the Physical Fitness Index (PFI) using the modified submaximal 3-minute Harvard Step Test, alongside secondary quality of life outcomes (SF-12 questionnaire), to prove that active cardiovascular training reverses physical deconditioning where iron supplements alone fall short.

Conditions

  • Iron Deficiency Anemia Treatment
  • Iron Deficiency Anemia (IDA)

Interventions

BEHAVIORAL

Treadmill Aerobic Exercise

Supervised progressive treadmill walking program for 8 weeks, 3 times/week. Each session lasted 35-40 minutes including 5 minutes warm-up (at 2.0-3.0 km/h), 25-30 minutes active aerobic walking at 60-70% of age-predicted max HR, and 5 minutes cool-down.

OTHER

Standard Medical Care and Nutritional Protocol

All participants in both groups received standard physician-prescribed medical care (including oral iron supplementation) and a standardized, culturally tailored, cost-effective nutritional protocol rich in heme and non-heme iron with absorption enhancers (e.g., Vitamin C) and restriction of iron inhibitors.

Sponsors & Collaborators

  • Horus University

    collaborator OTHER

  • Cairo University

    lead OTHER

Principal Investigators

  • Nesreen Gharib Elnahas, Prof. Dr. · Cairo University

  • Farag A. Ali, Prof. Dr. · Cairo University

  • Asmaa Mohammed Sharabash, Assistant Professor · Cairo University

  • Mohamed Salah Saleh, M.Sc. · Cairo University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
28 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-11-15
Primary Completion
2026-01-15
Completion
2026-01-15

Countries

  • Egypt

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07651098 on ClinicalTrials.gov