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Postoperative Non-Opioid Pain Management Utilizing Local Anesthetics Coupled With Modulated Coagulation

NCT07644923 · Status: NOT_YET_RECRUITING · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 40

Last updated 2026-06-12

No results posted yet for this study

Summary

This study is a prospective randomized trial examining the effect of tranexamic acid (TXA) and aminocaproic acid (ε-Ahx) with local anesthetics and thrombin in all electively created surgical wound beds in hand surgery to provide long term pain relief and decrease the use of postoperative narcotics.

All surgical created wounds for any hand surgery will be treated in a randomized fashion with the following four arms:

1. Bupivacaine + lidocaine
2. Bupivacaine + lidocaine + thrombin
3. Bupivacaine + lidocaine + thrombin + tranexamic acid
4. Bupivacaine + lidocaine + thrombin + aminocaproic acid

All are applied topically to surgical bed prior to closure of skin.

Conditions

  • Postoperative Pain

Interventions

DRUG

Bupivacaine

5 ml of 0.25% bupivacaine

DRUG

Lidocaine

5 ml of 1% lidocaine

DRUG

Thrombin

10000 units of thrombin

DRUG

Tranexamic acid

500 mg of tranexamic acid

DRUG

Aminocaproic acid

1000 mg of aminocaproic acid

Sponsors & Collaborators

Principal Investigators

  • David Chiu, MD · NYU Langone Health

Study Design

Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-08-01
Primary Completion
2028-08-01
Completion
2029-02-01
FDA Drug
Yes

Countries

  • United States

Study Locations

More Related Trials

Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07644923 on ClinicalTrials.gov