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Natural Course and Molecular Basis of Alpha 1- Antitrypsin Deficiency-associated Liver Disease.

NCT07639996 · Status: NOT_YET_RECRUITING · Type: OBSERVATIONAL · Enrollment: 45

Last updated 2026-06-10

No results posted yet for this study

Summary

* To define the course of AATD-associated liver disease.
* To use the obtained samples for biomedical research which includes:

1. Search for serum-based disease biomarkers and the associated molecular pathways.
2. Multi-omic spatial analysis of human AATD-LD.

Conditions

  • Alpha 1-antitrypsin Deficiency (AATD)

Interventions

DIAGNOSTIC_TEST

Multi-omic spatial analysis

conduction of spatial multi-omic analyses comparing pediatric and adult liver tissues. This will include proteomic and transcriptomic mapping to understand how AAT accumulation and ductular reactions differ between the two forms.

Sponsors & Collaborators

  • Assiut University

    lead OTHER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-10-01
Primary Completion
2027-09-30
Completion
2028-09-30

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07639996 on ClinicalTrials.gov