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UNderstanding the Causes Of Idiopathic Scoliosis Through the Longitudinal Analysis of Proteomic Markers: the UNCOIL Study

NCT07634627 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 500

Last updated 2026-06-23

No results posted yet for this study

Summary

The goal of this observational study is to find clinical, demographic, and protein biomarkers that scoliosis progression (scoliosis curve increases) and/or differ between participants with scoliosis versus those without scoliosis. The investigators aim to answer the following questions:

1. Are age, sex, skeletal maturity, and family history associated with scoliosis curve progression?
2. Do protein levels differ between progressive and non-progressive cases?
3. Do protein levels change between baseline and follow-up visits in progressive and non-progressive scoliosis cases?
4. Do proteins differ between participants with AIS vs those without AIS?
5. Do proteins or change in proteins differ between participants with AIS vs those with scoliosis secondary to neuromuscular conditions.

Participants will:

* Participate in two research visits 6-12 months apart at a Children's Hospital Colorado location.
* Participate in a blood draw at each study visit to collect about 3 tablespoons of blood.
* Fill out surveys yearly regarding new medical visits, pain, physical function, anxiety and depression, medical and family history, and current medications.

Conditions

  • Adolescent Idiopathic Scoliosis (AIS)
  • Neuromuscular Scoliosis

Sponsors & Collaborators

  • University of Colorado, Denver

    lead OTHER

Principal Investigators

  • Patrick Carry, PhD · University of Colorado, Denver

Eligibility

Min Age
10 Years
Max Age
17 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2024-12-05
Primary Completion
2029-12-31
Completion
2031-12-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07634627 on ClinicalTrials.gov