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Identification of Circulating microRNAs in Adolescent Idiopathic Scoliosis

NCT04746586 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 30

Last updated 2026-05-22

No results posted yet for this study

Summary

The aim of the present study is to evaluate the expression of a large panel of microRNAs, already known and validated in other ortopedic pathologies and bone metabolism, in the plasma of Adolescent Idiopathic Scoliosis (AIS) patients. The deregulated microRNAs identified will be then validated and computational analyzes will determine their potential involvement in the metabolism of bone and/or cartilage tissue in order to correlate the results obtained with the clinical data of the AIS patients. The investigators aimed to develop a microRNAs panel to further validate in a larger population of AIS patients in order to produce a device for the diagnosis and prognosis of Molecular-based AIS.

Conditions

  • Adolescent Idiopathic Scoliosis

Interventions

OTHER

Circulating MiRNA indentification

Identification of circulating miRNA useful to discriminate between worsening and stable forms of AIS

Sponsors & Collaborators

  • Istituto Ortopedico Rizzoli

    lead OTHER

Principal Investigators

  • Angelo Toscano, MD · Istituto Ortopedico Rizzoli

Eligibility

Min Age
11 Years
Max Age
17 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2020-07-22
Primary Completion
2022-08-31
Completion
2025-12-21

Countries

  • Italy

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04746586 on ClinicalTrials.gov