MedTrace Logo

Early Molecular Biomarkers for Differentiating Parkinsonian Syndromes

NCT07604883 · Status: NOT_YET_RECRUITING · Type: OBSERVATIONAL · Enrollment: 200

Last updated 2026-05-22

No results posted yet for this study

Summary

This prospective observational study aims to identify and preliminarily validate molecular biomarkers, including microRNAs and metabolites, for early differentiation between Parkinson's disease (PD) and atypical parkinsonian syndromes (APS). The study will enroll up to 100 PD patients, 50 suspected APS patients, and 50 healthy controls. Participants will undergo clinical assessments and provide blood, urine, and stool samples at baseline and after 12-18 months. Molecular analyses (microRNA profiling, metabolomics, RNA-seq, and microbiome analysis) will be performed to identify diagnostic signatures. The primary goal is to detect differences in molecular profiles, while secondary objectives include evaluating the diagnostic accuracy of biomarker panels and their changes over time. Although participants will not receive direct therapeutic benefits, the study may contribute to the development of non-invasive tools for early diagnosis and improved differentiation of parkinsonian disorders

Conditions

  • PARKINSON DISEASE (Disorder)
  • Atypical Parkinsonism
  • Multiple System Atrophy
  • Progressive Supranuclear Palsy (PSP)
  • Dementia With Lewy Bodies (DLB)

Sponsors & Collaborators

  • Medical University of Warsaw

    collaborator OTHER

  • Medical Centre for Postgraduate Education

    collaborator UNKNOWN

  • International Institute of Molecular and Cell Biology in Warsaw

    lead OTHER_GOV

Principal Investigators

  • Jacek Kuźnicki · The International Institute of Molecular and Cell Biology in Warsaw

Eligibility

Min Age
40 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-06-04
Primary Completion
2029-01-04
Completion
2029-06-04

Countries

  • Poland

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07604883 on ClinicalTrials.gov