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Identifying the Microbial Metabolome: The Missing Link Between Diet and Human Health

NCT07591961 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 7

Last updated 2026-05-18

No results posted yet for this study

Summary

There is a lot of evidence to suggest that the bacteria in our gut play a major role in maintaining our health, but very little is known about the way in which this is achieved. In this study we will identify how the bacteria in out gut change the food we eat into products that may be responsible for this effect. We will also identify which bacteria are responsible for these changes. The foods we will look at are those suggested by the American Institute of Cancer Research to help prevent cancer; leafy green vegetables (cabbage, spinach), soft fruits (strawberry) cereal (oats) and plant-based protein (soya and pea). We will feed a diet rich in these foods to volunteers, monitoring the changes to the bacteria in our gut and the products produced. We will identify which products have potential to prevent cancer and also to work out how they are being produced. This work will provide new and important information that will allow us to understand more about the link between diet and health.

Conditions

  • Inflammation Gastrointestinal Tract

Interventions

DIETARY_SUPPLEMENT

Food

The intervention products will be consumed as bread rolls, each containing 33.3 g of the intervention product. Three rolls will be consumed per day during the five day intervention period, in addition to the prescribed low-phytochemical diet.

Sponsors & Collaborators

  • National Cancer Institute (NCI)

    collaborator NIH

  • University of Aberdeen

    lead OTHER

Principal Investigators

  • Wendy R Russell, PhD · University of Aberdeen Rowett Institute

Study Design

Allocation
NON_RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
55 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2016-05-23
Primary Completion
2019-08-30
Completion
2019-09-04

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07591961 on ClinicalTrials.gov