MedTrace Logo

Effectiveness of Surgery for Improving Survival in Oligometastatic Breast Cancer Patients

NCT07586319 · Status: ENROLLING_BY_INVITATION · Phase: NA · Type: INTERVENTIONAL · Enrollment: 110

Last updated 2026-05-19

No results posted yet for this study

Summary

Breast cancer is the most common malignancy in women, with stage IV disease at diagnosis in 5-10% of cases. Oligometastatic breast cancer (OMBC), defined as limited metastases (≤3-5 in ≤1-2 organs), may have better outcomes. Systemic therapy is the cornerstone of treatment, while the role of surgery or radiotherapy for the primary tumour remains controversial. Current European Society for Medical Oncology(ESMO )and National Comprehensive Cancer Network(NCCN) guidelines advise systemic therapy as standard, reserving surgery mainly for palliation of local disease. Few Retrospective studies offering primary tumour surgery to oligometastatic breast cancer responding to systemic therapy suggest survival benefit, but several randomised trials to date showed inconsistent results. In Pakistan, data regarding survival pattern after breast surgery in oligometastatic breast cancer are scanty and this study would bridge this knowledge gap.

Conditions

  • Survival Outcomes

Interventions

PROCEDURE

surgery in accordance with current clinical guidelines

MRM or BCS

PROCEDURE

modified radical mastectomy or breast conservation surgery

patients who receive systemic therapy and respond to treatment will undergo modified radical mastectomy or breast conservation surgery

Sponsors & Collaborators

  • Sharif Medical Research Center

    lead OTHER

Principal Investigators

  • GHAZIA QASMI, FCPS SURGERY · SHARIF MEDICAL AND DENTAL COLLEGE, LAHORE.PAKISTAN

  • HAROON J. MAJID, FRCS SURGERY · SHARIF MEDICAL AND DENTAL COLLEGE LAHORE,PAKISTAN

Study Design

Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-06-01
Primary Completion
2028-06-01
Completion
2031-06-01

Countries

  • Pakistan

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07586319 on ClinicalTrials.gov