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Eccentric Exercise, Muscle Damage, and Oxygen Uptake Across Menstrual Cycle Phases

NCT07581067 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 12

Last updated 2026-05-15

No results posted yet for this study

Summary

The existing literature examining the effect of female sex hormones across the phases of the menstrual cycle on muscle microdamage and oxygen uptake is limited. The protective role of estrogens against muscle microdamage is supported by findings from some studies; however, it is questioned by others. The aim of the present study was to investigate the effect of eccentric exercise on biomarkers of muscle microdamage and on oxygen uptake during two phases of the menstrual cycle in healthy premenopausal women.

Conditions

  • Menstrual Cycle
  • Exercise Performance Impairment

Interventions

OTHER

Isokinetic eccentric exercise using knee extensors of the right lower limb

Isokinetic eccentric exercise consisted of 10 min at 40% of maximal voluntary contractions, followed by 2 min maximal intensity muscle effort

OTHER

Isokinetic eccentric exercise using knee extensors of the left lower limb

Isokinetic eccentric exercise consisted of 10 min at 40% of maximal voluntary contractions, followed by 2 min maximal intensity muscle effort

Sponsors & Collaborators

  • National and Kapodistrian University of Athens

    lead OTHER

Principal Investigators

  • Vassilis Paschalis, PhD · National and Kapodistrian University of Athens

Study Design

Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
28 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-05-15
Primary Completion
2025-08-05
Completion
2026-01-22

Countries

  • Greece

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07581067 on ClinicalTrials.gov