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Effects of Exercise-Induced Muscle Damage on Neuromuscular Complexity

NCT07565376 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 11

Last updated 2026-05-04

No results posted yet for this study

Summary

This study will examine the effects of exercise-induced muscle damage, induced by eccentric exercise, on torque production, muscle oxygenation, and electromyographic activity of the knee extensors in healthy young men. Eleven participants will perform a sustained submaximal isometric contraction before and 48 hours after a muscle-damaging eccentric exercise protocol. It is anticipated that the eccentric exercise will confirm the presence of muscle damage, by decrease in maximal voluntary isometric torque, increase in muscle soreness, and reduction in pain-free range of motion. The effect of eccentric exercise on the complexity of torque output, which could be reflected by decreased Sample Entropy and increased DFA α, will be indicated by a possible shift toward more predictable and less adaptable motor control patterns. Based on these results, the investigators will know about the effect of eccentric exercise induced muscle damage on neuromuscular efficiency, that is greater neural input could be required to maintain the same mechanical output, as well as increased oxygen consumption in the active muscle.

Conditions

  • Eccentric Exercise
  • Muscle Damage

Interventions

OTHER

Isokinetic eccentric exercise

Isokinetic eccentric exercise consisted of 5 sets of 15 repetitions using the knee extensors. The intensity of the exercise was the maximal voluntary and an interval of 1 minute was applied between sets.

Sponsors & Collaborators

  • National and Kapodistrian University of Athens

    lead OTHER

Principal Investigators

  • Vassilis Paschalis, Dr. · National and Kapodistrian Univesity of Athens

Study Design

Allocation
NON_RANDOMIZED
Purpose
OTHER
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
30 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-08-20
Primary Completion
2026-01-20
Completion
2026-03-30

Countries

  • Greece

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07565376 on ClinicalTrials.gov