Outcomes Tracking in Unilateral Vocal Fold Paralysis (UVFP) and Atrophy After Medialization Laryngeal Surgery

Summary

The goal of this observational study is to learn about the long-term outcomes of Laryngeal Framework Surgery (LFS) in patients with Unilateral Vocal Fold Paralysis (UVFP) or Vocal Fold Atrophy (VFA). The main questions it aims to answer are:

* Whether LFS technique (implant material, addition of arytenoid adduction) is associated with differences in outcomes such as complication rate, duration of surgery, hospital stay length, and quality of voice post-surgery.
* Whether UVFP or VFA diagnosis is associated with differences in outcomes such as complication rate, duration of surgery, hospital stay length, and quality of voice post-surgery.

Participants who are determined by their clinician to need LFS for their UVFP or VFA will undergo the procedure, attend follow-up appointments, and complete surveys about their voice and swallowing ability as they would as part of their regular medical care.

Conditions

• Unilateral Vocal Cord Paralysis
• Vocal Cord Atrophy

Interventions

PROCEDURE

Laryngeal Framework Surgery

All participants will receive laryngeal framework surgery as recommended by their treating surgeon. This can include medialization thyroplasty with or without arytenoid adduction, under general anesthesia or monitored anesthesia care.

Sponsors & Collaborators

• Massachusetts Eye and Ear Infirmary

  collaborator OTHER

• University of California, San Diego

  collaborator OTHER

• Wake Forest University

  collaborator OTHER

• University of Cincinnati

  collaborator OTHER

• University of Miami

  collaborator OTHER

• Ohio State University

  collaborator OTHER

• Washington University School of Medicine

  collaborator OTHER

• University of Southern California

  collaborator OTHER

• Medical University of South Carolina

  collaborator OTHER

• University of California, San Francisco

  lead OTHER

Principal Investigators

• Clark Rosen, MD · University of California, San Francisco

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2025-10-28

Primary Completion

2028-01-31

Completion

2028-01-31

Countries

• United States

Study Locations