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Corneal Epithelial Allograft From Living-related Donor for LSCD

NCT03217435 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 20

Last updated 2020-02-28

No results posted yet for this study

Summary

The purpose of the study is to explore whether femtosecond laser-assisted corneal epithelial allograft from living-related donor is more effective than limbal conjunctival allograft from living-related donor for ocular surface reconstruction in patients with limbal stem cell deficiency (LSCD).

Conditions

  • Limbal Stem Cell Deficiency

Interventions

PROCEDURE

Corneal epithelial allograft

A living-related donor's epithelial flap, equal in area to the recipient's diseased cornea bed, will be created using femtosecond laser technology. This corneal epithelial allograft is then ready for transplantation on the recipient's disease eye, following removal of the recipient's scarred and diseased epithelium.

PROCEDURE

Limbal conjunctival allograft

A 3- to 5- clock hour limbal-conjunctival allograft will be obtained from the living-related eye. This is then ready for transplantation on the recipient's disease eye following removal of the recipient's scarred and diseased epithelium.

DEVICE

Femtosecond laser

A commercial femtosecond laser to create a particular shaped graft for transplantation

DEVICE

Diamond knife

A diamond knife to create a particular shaped limbal graft for transplantation

Sponsors & Collaborators

  • Chunxiao Wang

    lead OTHER

Principal Investigators

  • Yizhi Liu, M.D.Ph.D. · Zhongshan Ophthalmic Center, Sun Yat-sen University

  • Ting Huang, M.D.Ph.D. · Zhongshan Ophthalmic Center, Sun Yat-sen University

Study Design

Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
14 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-07-27
Primary Completion
2019-11-13
Completion
2019-11-13

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03217435 on ClinicalTrials.gov