Engaging Family Members During Early SUD Treatment: A Hybrid Trial

Summary

The goal of this study is a fractional factorial optimization trial to optimize engagement in a CRAFT program for family members with loved ones in outpatient treatment for a substance use disorder.

This study aims to identify family engagement strategies that are feasible, acceptable, and appropriate and effective in increasing family member initiation with CRAFT. Participants will complete an iterative, online process where they will evaluate and rank different engagement strategies to identify the most optimal in increasing engagement and then participate in an optimization trial to identify which strategies were most effective in increasing family member engagement.

Conditions

• Substance Use Disorder (SUD)

Interventions

BEHAVIORAL

Engagement Strategy 1

Engagement Strategy

BEHAVIORAL

Engagement Strategy 2

Engagement Strategy

BEHAVIORAL

Engagement Strategy 3

Engagement Strategy

BEHAVIORAL

Engagement Strategy 4

Engagement Strategy

BEHAVIORAL

Placebo

No engagement strategies

Sponsors & Collaborators

• National Institute on Drug Abuse (NIDA)

  collaborator NIH

• RAND

  collaborator OTHER

• Northern California Institute of Research and Education

  collaborator OTHER

• Family Health Centers of San Diego

  collaborator OTHER

• Stanford University

  lead OTHER

Principal Investigators

• Karen Osilla, PhD · Stanford University

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

FACTORIAL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2026-07-15

Primary Completion

2027-01-31

Completion

2027-03-31

Countries

• United States

Study Locations