Infusion of Furosemide to Improve Diuretic Efficiency in Acute Heart Failure

Summary

Acute heart failure is a condition where the heart suddenly cannot pump blood well enough for the body's needs. Many people admitted to the hospital with acute heart failure have too much fluid in the body. This can cause shortness of breath, swelling, and the need for treatment with water-removing medicine.

Furosemide is a commonly used water-removing medicine that is given into a vein to treat fluid overload. It can be given in different ways. One way is as a continuous infusion, where the medicine is given slowly over time through a pump. Another way is as repeated injections given several times a day. It is not known whether one of these ways is better than the other for removing excess fluid in people with acute heart failure.

The purpose of this study is to compare two ways of giving furosemide into a vein: Continuous infusion started with an initial extra dose, and bolus injections given three times a day. About 436 adults admitted to hospitals in Denmark with acute heart failure and fluid overload will take part. Participants will be randomly assigned to one of the two treatment groups. This means that chance will decide which treatment method each participant receives.

The main thing the researchers will measure is how much body weight participants lose about 3 days after randomization. Weight loss is used as a measure of how much excess fluid has been removed.

Conditions

• Acute Heart Failure
• Volume Overload

Interventions

DRUG

Intravenous furosemide continuous infusion

Intravenous furosemide administered as a continuous infusion preceded by a loading dose. Daily intravenous furosemide doses are determined according to the participant's oral loop diuretic dose at hospital admission using a predefined dosing algorithm.

DRUG

Intravenous furosemide bolus injections

Intravenous furosemide administered as bolus injections three times a day. The first bolus injection includes an additional dose to mirror the loading dose strategy used in the continuous infusion group. Daily intravenous furosemide doses are determined according to the participant's oral loop diuretic dose at hospital admission using a predefined dosing algorithm.

Sponsors & Collaborators

• Central Denmark Region

  collaborator OTHER

• University of Aarhus

  lead OTHER

Principal Investigators

• Esben Merrild, MD · Department of Medicine, Randers Regional Hospital

• Bo Løfgren, MD PhD · Department of Medicine, Randers Regional Hospital

• Henrik Birn, MD PhD DMSc · Department of Renal Medicine, Aarhus University Hospital

• Kasper G Lauridsen, MD PhD · Department of Medicine, Randers Regional Hospital

• Christian B Poulsen, MD PhD · Private Organization

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2026-05-01

Primary Completion

2027-09-01

Completion

2027-10-01