Acute Heart Failure - COngestion Repeated Evaluation (AHF-CORE)

Summary

The AHF-CORE study is a prospective, non-randomized, multicenter regional study.

The main objective of the AHF-CORE study is to identify congestion markers (clinical, biological and ultrasound) at the beginning and at the end of hospitalization for acute heart failure that are more strongly associated with the risk of all cause death or rehospitalization for acute heart failure within 3 months of hospital discharge.

Secondary objectives are:

* Quantify the variations in congestion markers between the beginning and end of hospitalization for acute heart failure.
* Assess the correlation between changes in congestion markers between the beginning and end of hospitalization.
* Identify the congestion markers at the beginning of hospitalization that are most strongly associated with residual congestion at the end of hospitalization.
* Identify the added value of ultrasound and biological markers of congestion in addition to clinical variables for the prediction of all-cause death or hospitalization for acute heart failure at 3 months after hospital discharge.
* Identify the association of ultrasound and biologic congestion markers assessed at admission and final discharge with NYHA class at 3 months after hospital discharge

Conditions

• Acute Heart Failure

Interventions

PROCEDURE

Clinical examination centered on congestion

Clinical examination centered on congestion will be performed within 72 hours of admission and before discharge from hospital

PROCEDURE

Cardio-pulmonary and peritoneal ultrasound

Cardio-pulmonary and peritoneal ultrasound will be performed within 72 hours of admission and before discharge from hospital

BIOLOGICAL

Blood sample retrieved for biological assessment and biobanking

Blood sample collection will be performed within 72 hours of admission and before discharge from hospital

OTHER

Telephone interview

Telephone interview will be performed 3, 12 and 24 months after discharge from hospital

BIOLOGICAL

Urinary sample retrieved for biological assessment and biobanking

Urinary sample collection will be performed within 72 hours of admission and before discharge from hospital

PROCEDURE

jugular and renal ultrasound (optional)

optional jugular and renal ultrasound performed within 72hours of admission and before discharge from hospital

Sponsors & Collaborators

• Central Hospital, Nancy, France

  lead OTHER

Principal Investigators

• Nicolas GIRERD, MD,PhD · Centre d'Investigation Clinique 1433 module Plurithématique de Nancy

Study Design

Allocation

NA

Purpose

OTHER

Masking

NONE

Model

SINGLE_GROUP

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2018-02-13

Primary Completion

2024-05-31

Completion

2026-02-28

Countries

• France

Study Locations