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A Study of PF-08653945 and PF-08653944 in Adults With Overweight or Obesity (SOLIS-1)

NCT07575932 · Status: NOT_YET_RECRUITING · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 872

Last updated 2026-05-08

No results posted yet for this study

Summary

This study is being done to learn about the safety and effects of the study drugs, PF-08653945 and PF-08653944, when given alone or together for weight loss, compared to a placebo (a dummy drug that has no active ingredient in it).

Conditions

  • Overweight
  • Obesity
  • Overweight and/or Obesity
  • Overweight or Obesity
  • Overnutrition
  • Nutrition Disorders
  • Nutritional and Metabolic Diseases
  • Body Weight

Interventions

DRUG

PF-08653945

Subcutaneous Injection

DRUG

PF-08653944

Subcutaneous Injection

DRUG

Placebo

Subcutaneous Injection

Sponsors & Collaborators

Principal Investigators

  • Pfizer CT.gov Call Center · Pfizer

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-05-11
Primary Completion
2027-08-04
Completion
2028-01-05
FDA Drug
Yes

Countries

  • United States

Study Locations

More Related Trials

Entities

Drugs
Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07575932 on ClinicalTrials.gov