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Assessment of cfDNA-STING Axis as a Potential Pathological Marker in Atopic Dermatitis

NCT07573735 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 80

Last updated 2026-05-07

No results posted yet for this study

Summary

Study Overview Atopic dermatitis (AD), commonly known as eczema, is a chronic inflammatory skin condition characterized by intense itching and skin barrier damage. While researchers know that the immune system is overactive in AD, it is difficult to measure the exact level of "damage" or "inflammation" happening deep within the skin using only a physical exam.

The Purpose of This Study This study investigates a specific "danger signal" called circulating cell-free DNA (cfDNA). When skin cells are damaged or die due to inflammation, they release tiny fragments of DNA into the bloodstream. We believe these fragments might act as a trigger for the immune system, worsening the disease.

What the Study Involves

Researchers will collect blood samples and small skin biopsies from patients with AD and healthy volunteers. The study aims to:

Compare the levels of cfDNA in the blood of AD patients versus healthy individuals.

Determine if higher levels of cfDNA correlate with more severe skin symptoms (measured by scores like SCORAD and EASI).

Examine how immune cells in the skin (macrophages) respond to these DNA fragments through a specific biological switch called the STING pathway.

Potential Impact By understanding this "damage-signal" loop, this research may lead to new ways for doctors to monitor AD severity through simple blood tests and could identify new targets for future anti-inflammatory treatments.

Conditions

  • Atopic Dermatitis (Eczema)

Interventions

BIOLOGICAL

blood sampling

One-time peripheral venous blood collection and/or 4mm punch biopsy for biomarker analysis.

Sponsors & Collaborators

  • Zhongda Hospital

    lead OTHER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-02-01
Primary Completion
2026-05-01
Completion
2026-05-31

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07573735 on ClinicalTrials.gov