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Effects of Adolescent Synaptic Pruning

NCT07569718 · Status: ENROLLING_BY_INVITATION · Phase: NA · Type: INTERVENTIONAL · Enrollment: 60

Last updated 2026-05-06

No results posted yet for this study

Summary

The study will use a PET-based measure of brain cell (neuron) connections (synapses) in young adults who have also obtained an MRI, to assess how the loss of brain cell connections (synaptic pruning) is captured by MRI-based measures. This will inform youth MRI studies to understand neurotypical brain development that can help identify abnormal trajectories as in mental illness.

Conditions

  • Healthy Adult Participants
  • Synaptic Plasticity

Interventions

RADIATION

PET Imaging Scan using [11C]UCB-J

\[11C\]UCB-J (\~ 15 mCi and ≤ 6μg) will be injected as a slow intravenous bolus. Following an intravenous bolus injection of \[11C\]UCB-J, the participants will be positioned in the scanner for a low dose CT scan (for attenuation correction) fifty-five minutes after the \[11C\]UCB-J injection, and emission data will be collected.

Sponsors & Collaborators

  • National Institute of Mental Health (NIMH)

    collaborator NIH

  • Beatriz Luna

    lead OTHER

Principal Investigators

  • Beatriz Luna, PhD · University of Pittsburgh

Study Design

Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-01-09
Primary Completion
2028-06-30
Completion
2028-06-30

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07569718 on ClinicalTrials.gov