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Depression in Adolescents. A Cerebral Structural, Diffusion, and Functional Magnetic Resonance Imaging Study

NCT01857518 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 80

Last updated 2017-10-20

No results posted yet for this study

Summary

Adolescence is a critical period for the development of depressive disorders. As adolescence also is a critical period for brain maturation, it may be hypothesized that maturation changes in emotional circuits could underlie vulnerability for depression.

The aims of the study are (1) to identify the changes in brain morphometry, white matter microstructure, and functioning, in networks associated with depression features in adolescents, and (2) to assess the effects of treated pathology on brain structure by comparing the neuroimaging measures obtained in adolescents at inclusion with those at follow-up.

Conditions

  • Adolescent Depression

Interventions

OTHER

-Diagnostic, clinical and psycho-behavioral assessments -Neuroimaging: T1-MRI, DTI-MRI, fMRI

* Visit V1: Diagnostic and clinical assessments * Visit V2: psycho-behavioral assessment and neuroimaging * Visit V3: Diagnostic and clinical assessments * Visit V4: psycho-behavioral assessment and neuroimaging

Sponsors & Collaborators

  • CENIR Centre de Neuroimagerie de Recherche, Paris

    collaborator UNKNOWN

  • Inserm CEA Research unit U1000 (Neuroimaging in psychiatry)

    collaborator UNKNOWN

  • National Research Agency, France

    collaborator OTHER

  • Assistance Publique - Hôpitaux de Paris

    collaborator OTHER

  • Centre Hospitalier St Anne

    lead OTHER

Principal Investigators

  • Marie-Laure PAILLERE MARTINOT, MD, PhD · APHP

Study Design

Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
FACTORIAL

Eligibility

Min Age
15 Years
Max Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2013-08-31
Primary Completion
2018-02-28
Completion
2018-03-31

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01857518 on ClinicalTrials.gov