Improving Patient Assessment After Acute Kidney Injury (AKI)

Summary

The goal of this clinical trial is to improve patient care after acute kidney injury (AKI). It has three related parts. The main questions it aims to answer are:

1. Is creatinine or cystatin a more reliable assessment of kidney function after AKI?
2. What are the experiences of patients after AKI?
3. What interventions should be recommended to improve assessment and support of patients after AKI?

Participants will be asked to do one or more of:

* blood tests to measure kidney function in different ways
* have measurement of their body composition
* complete questionnaires about their symptoms
* have an interview with a researcher about their experiences
* discussion to develop an action plan based on findings

Conditions

• Acute Kidney Injury

Interventions

DIAGNOSTIC_TEST

Iohexol renal clearance measurement

Gold standard measurement of glomerular filtration rate.

DIAGNOSTIC_TEST

Cystatin C

Estimated GFR using serum cystatin C

DIAGNOSTIC_TEST

Creatinine

eGFR from serum creatinine level

OTHER

Semi structured interview

Semi structured interview to explore patient experiences. Purposive sampling will be used to explore a wide range of perspectives and transcripts will be analysed using thematic analysis to develop codes and themes.

OTHER

Participatory workshop

Group workshop using qualitative methods. Purposive sampling will be used to explore a wide range of perspectives and transcripts will be analysed using thematic analysis to develop codes and themes. These will be used to develop consensus recommendations.

DIAGNOSTIC_TEST

Metagenome analysis

Analysis of the metagenome using faecal samples of participants after acute kidney injury

DIAGNOSTIC_TEST

Bioimpedance analysis

Estimation of body composition

OTHER

Patient reported outcome measures

EQ-5D-5L, KSQ, WHO-DAS 2.0, K10

OTHER

Measurement of physical performance

Hand grip, Short physical performance battery

Sponsors & Collaborators

• University Hospitals of Derby and Burton NHS Foundation Trust

  collaborator OTHER

• University of Nottingham

  lead OTHER

Principal Investigators

• Nicholas Selby · University of Nottingham

Eligibility

Min Age

18 Years

Max Age

85 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2026-02-16

Primary Completion

2028-01-31

Completion

2029-10-31

Countries

• United Kingdom

Study Locations