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Low-Load BFR vs. High-Load Training on Biceps Hypertrophy

NCT07561281 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 33

Last updated 2026-05-07

No results posted yet for this study

Summary

This study aimed to compare the effects of low-load blood flow restriction resistance exercise (BFR-RE) performed to voluntary failure with traditional high-load resistance exercise (HL-RE) and a control condition on biceps brachii muscle hypertrophy, muscle stiffness, and maximal strength in untrained young men.

Participants completed an 8-week training program, with exercise performed three times per week. Outcomes were assessed using ultrasound imaging, elastography, and one-repetition maximum (1RM) testing. The study evaluates whether low-load BFR training can produce adaptations comparable to high-load resistance training.

Conditions

  • Muscle Hypertrophy

Interventions

DEVICE

Blood Flow Restriction Resistance Exercise

Resistance exercise was performed under partial vascular occlusion using a pneumatic cuff applied to the upper arm. Limb occlusion pressure was individually determined, and exercise was conducted at a relative intensity corresponding to a percentage of one-repetition maximum. Occlusion pressure was maintained during sets and released between exercises. Training load and repetition tempo were standardized and progressively adjusted throughout the intervention period.

BEHAVIORAL

High-Load Resistance Exercise

Participants performed resistance exercise using conventional loading strategies based on a percentage of one-repetition maximum. Training intensity, volume, and progression were standardized across sessions, with loads adjusted periodically according to performance assessments.

Sponsors & Collaborators

  • Karabuk University

    collaborator OTHER

  • Mehmet Akif Ersoy University

    lead OTHER

Study Design

Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
30 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-06-01
Primary Completion
2025-08-03
Completion
2025-08-03

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07561281 on ClinicalTrials.gov