Weight Loss and Endocrine Disrupting Chemicals (EDCs): Lifestyle Interventions to Lose Weight and Reduce EDC Exposure in Individuals With Overweight/Obesity

Summary

The goal of this study is to examine the relationship in individuals with overweight/obesity and endocrine disrupting chemical (EDC) exposure through a two-armed, randomized clinical trial. The main questions this study aims to answer are:

1. If MM's 12-week EDC intervention program (EDC testing and report-back, EDC reduction curriculum) can reduce weight?
2. If a 12-week validated digital weight loss program can reduce EDC exposures?
3. What is the effectiveness of the two interventions at reducing weight and urinary EDC metabolites? Participants will be assigned to one of these two arms. Participants will collect their urine and blood samples pre- and post-intervention, and will take a comprehensive exposure survey before sending back their samples. This exposure survey will ask about participant's weight loss literacy, environmental health literacy, product use, diet, and lifestyle behaviors.

Conditions

• Obesity &Amp;Amp;Amp; Overweight
• Environmental Exposure
• Overweight (BMI > 25)

Interventions

BEHAVIORAL

Educational curriculum

A self-directed online interactive curriculum of EDC material, with access to live coaches and an online forum.

BEHAVIORAL

Weight loss Application

A paid, self-directed weight loss application.

DIAGNOSTIC_TEST

Urinary EDC metabolite testing

Mail-in urine samples tested for metabolites of bisphenols, phthalates, parabens, and oxybenzone.

DIAGNOSTIC_TEST

Siphox clinic biomarker test

Mail-in blood samples tested for clinical biomarkers.

DIAGNOSTIC_TEST

Weight loss reporting

Self-reported weight loss.

Sponsors & Collaborators

• National Institute of Environmental Health Sciences (NIEHS)

  collaborator NIH

• Mayo Clinic

  collaborator OTHER

• Million Marker Wellness, Inc.

  lead INDUSTRY

Principal Investigators

• Johanna R Rochester, PhD · Million Marker Wellness

Study Design

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

SINGLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2025-08-18

Primary Completion

2026-08-31

Completion

2026-09-30

Countries

• United States

Study Locations