MedTrace Logo

Histological and Clinical Evaluation of De-epithelialized Connective Tissue Grafts Obtained by Different Methods

NCT07521566 · Status: ACTIVE_NOT_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 48

Last updated 2026-04-13

No results posted yet for this study

Summary

This randomized controlled clinical study aimed to evaluate the effectiveness of two different de-epithelialization techniques-extraoral scalpel and intraoral radiofrequency (RF)-used in the preparation of de-epithelialized connective tissue grafts (De-CTG) for the treatment of gingival recession. A total of 48 patients were randomly assigned into two groups, and all grafts were applied in combination with coronally advanced flap (CAF) surgery. Clinical and histological outcomes, including epithelial remnants, root coverage, keratinized tissue gain, surgical duration, and postoperative patient comfort, were assessed. The study seeks to identify a reliable, operator-independent method that minimizes epithelial remnants and improves clinical outcomes and patient experience.

Conditions

  • Gingival Recessions
  • Gingival Recession, Mucogingival Surgery

Interventions

PROCEDURE

Extraoral de-epithelialization Group

Extraoral de-epithelialization of connective tissue grafts using a scalpel prior to graft placement.

PROCEDURE

Radiofrequency De-epithelialization

Intraoral de-epithelialization of connective tissue grafts using a radiofrequency device prior to graft placement.

Sponsors & Collaborators

  • Dokuz Eylul University

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-09-19
Primary Completion
2025-10-06
Completion
2026-06-30

Countries

  • Turkey (Türkiye)

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07521566 on ClinicalTrials.gov