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i-PRF for Gingival Phenotype Modification

NCT07521527 · Status: ACTIVE_NOT_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 20

Last updated 2026-04-13

No results posted yet for this study

Summary

This randomized split-mouth clinical trial aims to evaluate the effectiveness of injectable platelet-rich fibrin (i-PRF) in thickening thin gingival phenotype and improving soft tissue conditions around teeth.

Thin gingival tissue is an important risk factor for gingival recession and may negatively affect periodontal health and esthetic outcomes. This study investigates whether the use of i-PRF, obtained from the patient's own blood, can enhance gingival thickness and support tissue healing.

Following initial periodontal therapy, the procedure will be performed under local anesthesia. A minimally invasive approach will be applied to the gingival tissue, and i-PRF prepared from the patient's blood will be injected into the treatment area. The procedure will be repeated in multiple sessions at regular intervals. Patients will receive standard post-operative care and instructions.

Clinical parameters will be evaluated at follow-up visits, and gingival thickness will be measured using ultrasonography over a 6-month period.

Possible risks include mild pain, bleeding, infection, and temporary discomfort, all of which are manageable with routine clinical care.

This study is expected to contribute to the development of minimally invasive and biologically based treatment approaches, reduce the need for additional surgical procedures, and improve periodontal and esthetic outcomes.

Conditions

  • Thin Gingival Biotype

Interventions

PROCEDURE

Injectable Platelet-Rich Fibrin (i-PRF) with and without Minimally Invasive Technique

Injectable platelet-rich fibrin (i-PRF) will be prepared from the participant's venous blood using a low-speed centrifugation protocol without anticoagulants. The obtained liquid fibrin will be applied to gingival tissues with a thin phenotype. After initial periodontal therapy, the procedure will be performed under local anesthesia using a minimally invasive semi-surgical approach. A small apical incision and gentle periosteal elevation will be performed to create space, followed by injection of i-PRF into the target area using a dental syringe. The procedure will be repeated at 10-day intervals for a total of four sessions. This intervention aims to enhance gingival thickness and improve soft tissue quality through the biological effects of autologous platelet concentrates, including growth factor release and angiogenesis.

Sponsors & Collaborators

  • Çanakkale Onsekiz Mart University

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-04-01
Primary Completion
2026-11-01
Completion
2027-01-01

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07521527 on ClinicalTrials.gov