Effect of Collagen Peptides on Skin Health: A Clinical Trial

Summary

The goal of this clinical trial is to evaluate whether daily oral supplementation with 2.5 g of specific bioactive collagen peptides (SCP) can improve skin physiology in healthy adult women aged 35-55 years. The main questions it aims to answer are:

Does SCP supplementation increase skin hydration and barrier function? Does SCP improve skin elasticity, firmness, and collagen content? Does SCP reduce the appearance of periorbital wrinkles and improve overall skin appearance? Researchers will compare SCP supplementation to a placebo (a look-alike substance containing no collagen peptides) to see if SCP supports skin structure and appearance over eight weeks.

Participants will:

Consume one sachet of SCP or placebo daily for eight weeks Attend three study visits at baseline, week 4, and week 8 for facial imaging, instrumental skin measurements, and expert assessments Have objective measures taken, including skin hydration, transepidermal water loss, elasticity, firmness, dermal collagen content, and 3D wrinkle morphology Complete subjective skin assessments rated by trained evaluators using a visual analogue scale Report any adverse events or intolerance reactions at each visit This study is designed to provide an integrated evaluation of multiple skin parameters, including barrier function, biomechanical properties, dermal matrix composition, and wrinkle characteristics, in a single trial. By combining objective and subjective measures, the study aims to generate robust and clinically interpretable evidence for the effects of oral collagen peptide supplementation on skin health.

Conditions

• Age-related Changes in Skin Appearance and Physiology

Interventions

DIETARY_SUPPLEMENT

Placebo

Participants in this arm receive a matching placebo sachet once daily for 8 weeks. The placebo contains plant-derived maltodextrin and is identical in appearance, taste, and texture to the collagen peptide supplement. It is dissolved in warm water and consumed orally. Participants continue their usual lifestyle habits while taking the placebo.

DIETARY_SUPPLEMENT

Specific Collagen Peptides

Participants in this arm receive 2.5 g of specific bioactive collagen peptides (VERISOL®) once daily for 8 weeks. The powder is dissolved in warm water and consumed orally. The supplement contains defined collagen peptides derived from bovine type I collagen, which have been shown to support skin hydration, elasticity, firmness, dermal collagen content, and wrinkle reduction. Participants continue their usual lifestyle habits while taking the supplement.

Sponsors & Collaborators

• GELITA

  collaborator INDUSTRY

• Collagen Research Institute

  lead INDUSTRY

Principal Investigators

• Steffen Oesser, Dr · Collagen Research Institute, Schauenburgerstr. 116, D-24118 Kiel

Study Design

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

QUADRUPLE

Model

PARALLEL

Eligibility

Min Age

35 Years

Max Age

55 Years

Sex

FEMALE

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2024-08-08

Primary Completion

2024-10-04

Completion

2024-10-04

Countries

• China

Study Locations