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JiGenerations Health Cohort Study：Parental Exposure and Intergenerational Health in China

NCT07514377 · Status: ACTIVE_NOT_RECRUITING · Type: OBSERVATIONAL · Enrollment: 100000

Last updated 2026-04-07

No results posted yet for this study

Summary

The growing recognition of maternal health's impact on offspring necessitates large-scale prospective cohort studies spanning the maternal-child life cycle. This study establishes a family-centered birth cohort of 100,000 Chinese participants, tracking from preconception through offspring adolescence to investigate early-life health trajectories and intergenerational transmission of diseases, health status, and psychological-behavioral patterns. Data collection includes biospecimens (placenta, cord blood, breast milk, blood, urine, feces) and multi-omics analysis (genomic, proteomic, metabolomic, microbiomic), alongside clinical information from preconception, pregnancy, birth through childhood (0-14 years). The cohort covers 24 stratified sites across China, incorporating real-time environmental monitoring (air pollution, meteorological data) and sociogeographic factors. Targeting reproductive-age couples (18-45 years) and their offspring, the study addresses multigenerational health linkages, urban-rural disparities, and regional diversity from 2025 to 2039. By integrating genetic, environmental and lifestyle data, this research will identify critical intervention windows and mechanisms for chronic disease transmission across generations, supporting China's "Healthy China" initiative and developing targeted strategies for population health and aging.

Conditions

  • Environmental Exposure
  • Fertility
  • Health Problems in Pregnancy
  • Adverse Pregnancy Outcomes
  • Birth Defects
  • Child Development
  • Metabolic Abnormality
  • Growth Retardation
  • Overweight and Obesity
  • Non-alcoholic Fatty Liver Disease

Interventions

OTHER

N/A (Observational Study)

This is an observational cohort study. No interventions are assigned. Groups are defined based on different condition or exposure.

Sponsors & Collaborators

  • West China Second University Hospital

    collaborator OTHER

  • National Research Institute for Family Planning, China

    lead OTHER_GOV

Principal Investigators

  • Yuan He · National Centre for Human Genetic Resources, National Research Institute for Family Planning

Eligibility

Min Age
1 Day
Max Age
45 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-08-01
Primary Completion
2039-12-31
Completion
2039-12-31

Countries

  • China

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07514377 on ClinicalTrials.gov