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Adipose Visceral and Epicardial Risk Evaluation

NCT07504679 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 400

Last updated 2026-04-01

No results posted yet for this study

Summary

The goal of this procedure-based interventional study without drugs or devices is to investigate the molecular mechanisms underlying metabolically unfavorable obesity and related clinical phenotypes, in order to identify non-invasive biomarkers capable of early prediction of metabolic syndrome, type 2 diabetes mellitus, MASLD, and cardiovascular disease in adult participants without known cardiovascular or liver disease.

The main questions it aims to answer are:

* What is the association between epicardial and visceral fat thickness and plasma levels of low-grade inflammatory biomarkers?
* How do these parameters relate to the presence of metabolic syndrome, type 2 diabetes mellitus, MASLD, and subclinical atherosclerosis?

Participants will:

* Undergo a comprehensive clinical evaluation, including demographic, anthropometric, and medical history data;
* Complete non-invasive diagnostic assessments, including 12-lead electrocardiogram, transthoracic echocardiography, liver elastography (FibroScan), and carotid Doppler ultrasound;
* Provide peripheral venous blood samples for biochemical, cellular, and molecular analyses.

Conditions

  • Subclinical Atherosclerosis

Interventions

OTHER

Peripheral blood sampling

Collection of blood specimens for biochemical, cellular, and molecular studies.

Sponsors & Collaborators

  • Fondazione Policlinico Universitario Agostino Gemelli IRCCS

    lead OTHER

Study Design

Allocation
NA
Purpose
PREVENTION
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-05-01
Primary Completion
2029-03-30
Completion
2029-12-31

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07504679 on ClinicalTrials.gov