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Tetris Intervention Following Subliminal Reactivation for Intrusive Memories

NCT07495917 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 106

Last updated 2026-04-06

No results posted yet for this study

Summary

Post-Traumatic Stress Disorder (PTSD) is characterized by recurrent, intrusive memories of traumatic events that cause significant distress and functional impairment. Although trauma-focused treatments are effective, they typically require deliberate recollection of traumatic experiences, which can be distressing and may contribute to treatment avoidance or dropout.

In previous experimental studies conducted with healthy participants, we demonstrated that unconscious reactivation of trauma-related cues, followed-after a brief delay corresponding to the memory reconsolidation window-by a visuospatial interference task (Tetris gameplay), reduced the frequency and emotional intensity of intrusive memories. These findings suggest that memory representations may be modifiable during reconsolidation without requiring conscious recall.

Building on this work, the present randomized controlled trial (RCT) aims to evaluate the clinical efficacy and tolerability of this reconsolidation-based intervention in trauma-exposed individuals experiencing five or more intrusive memories per week.

Conditions

  • Post-traumatic Stress Disorder (PTSD)
  • Intrusive Memories of Traumatic Event(s)

Interventions

BEHAVIORAL

Subliminal Reactivation

In each intervention session, participants are exposed subliminally to trauma-related cues and then complete a computerized visuospatial task (Tetris) with mental rotation instructions.

BEHAVIORAL

Computer-based Visuospatial Task (Tetris)

A computerized visuospatial task (Tetris) with mental rotation instructions.

Sponsors & Collaborators

  • Shaanxi Normal University

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
50 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-04-10
Primary Completion
2027-04-10
Completion
2027-07-30

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07495917 on ClinicalTrials.gov