MedTrace Logo

fMRI in Posttraumatic Stress Disorder (PTSD) During Working Memory Updating

NCT00288314 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 34

Last updated 2010-03-17

No results posted yet for this study

Summary

Neuropsychological studies investigating trauma-exposed and posttraumatic stress disorder (PTSD) subjects have generally underlined the significantly poorer performance of tasks that require attention, concentration, and verbal memory, and difficulty in regulating memories surrounding the traumatic event. A previous study (El Hage et al. Cognitive Neuropsychiatry, 2006) revealed that the trauma-exposed subjects scored higher on anxiety/depression scales, and lower on processing speed tests. Moreover, the study showed significant impairment in working memory partially mediated by speed processing, but not by anxiety or depression. These results suggest that processing speed makes a major contribution to trauma-related working memory decline, and needs to be investigated in further studies.The aim of the present study is to explore correlation between hippocampus volume, frontal dysfunction and cognitive slowing in trauma-exposed subjects, while examining brain activation during performance of working memory tasks using functional magnetic resonance.

Conditions

  • Post-Traumatic Stress Disorders
  • Anxiety
  • Amnesia, Dissociative

Interventions

PROCEDURE

Magnetic Resonance Imaging, Functional

Structural and functional MRI

Sponsors & Collaborators

  • University Hospital, Tours

    lead OTHER

Principal Investigators

  • Wissam EL HAGE, MD, PhD · UNIVERSITY HOSPITAL OF TOURS

Eligibility

Min Age
18 Years
Max Age
40 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2007-01-31
Primary Completion
2008-05-31
Completion
2008-05-31

Countries

  • France

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00288314 on ClinicalTrials.gov