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PROGAIN Trial in Gastric Cancer Surgery

NCT07488611 · Status: RECRUITING · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 110

Last updated 2026-05-19

No results posted yet for this study

Summary

This randomized study will evaluate whether protein-enriched parenteral nutrition improves early postoperative recovery in patients undergoing gastrectomy for gastric cancer. Participants will be assigned to receive either protein-enriched parenteral nutrition or standard parenteral nutrition during the perioperative period. The primary outcome is nitrogen balance on postoperative day 5. Secondary outcomes include postoperative complications, recovery of oral intake, and short-term changes in nutritional status and body composition.

Conditions

  • Stomach (Gastric) Cancer

Interventions

DRUG

Protein-enriched peripheral parenteral nutrition (Winuf A+ injection)

A novel, high-amino acid peripheral parenteral nutrition formulation (Winuf A+ injection; JW Pharmaceutical) designed to provide optimal protein delivery with lower glucose load. Administered intravenously.

DRUG

Standard peripheral parenteral nutrition (Winuf injection)

A conventional, standard 3-chamber peripheral parenteral nutrition formulation (Winuf injection; JW Pharmaceutical). Administered intravenously.

Sponsors & Collaborators

  • JW Pharmaceutical

    collaborator INDUSTRY

  • Soonchunhyang University Hospital

    lead OTHER

Principal Investigators

  • Geum Jong Song, MD, PhD · Soonchunhyang University Hospital

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
19 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-02-13
Primary Completion
2027-02-28
Completion
2028-03-31

Countries

  • South Korea

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07488611 on ClinicalTrials.gov