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Non-Surgical Treatment of Periodontitis With Adjunctive Sodium Hypochlorite/Amino Acids and Cross-Linked Hyaluronic Acid

NCT07474272 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 78

Last updated 2026-03-17

No results posted yet for this study

Summary

The goal of this clinical trial is to learn if using sodium hypochlorite/amino acid gel, with or without cross-linked hyaluronic acid, as an addition to standard non-surgical periodontal therapy works to treat periodontitis in adults. It will also learn about the safety of these treatments. The main questions it aims to answer are:

Does the adjunctive treatment reduce bleeding on probing, plaque index, and periodontal pocket depth?

What medical or dental problems do participants have when receiving these treatments?

Researchers will compare:

Standard non-surgical periodontal therapy alone

Standard therapy plus sodium hypochlorite/amino acid gel

Standard therapy plus sodium hypochlorite/amino acid gel and cross-linked hyaluronic acid ("Clean and Seal" protocol)

Participants will:

Receive their assigned treatment during one clinical session per the study protocol

Have clinical measurements taken before treatment and at three months after treatment

Be monitored for any dental or medical adverse events related to the procedures

Conditions

  • Periodontitis

Interventions

PROCEDURE

Standard Non-Surgical Periodontal Therapy

Standard Non-Surgical Periodontal Therapy based on the American Academy of Periodontology's guidelines: mechanical debridement with manual and ultrasonics

PROCEDURE

tandard Therapy + Sodium Hypochlorite/Amino Acid Gel

Participants receive the same standard care as Arm 1. In addition, a 0.9% sodium hypochlorite/amino acid gel is instilled into periodontal pockets with probing depth \>4 mm and left for 60 seconds before mechanical debridement. The gel application is repeated as needed until instrumentation is complete.

PROCEDURE

Standard Therapy + Sodium Hypochlorite/Amino Acid Gel + Cross-Linked Hyaluronic Acid

Participants receive the same treatment as Arm 2. After instrumentation, cross-linked hyaluronic acid gel is applied to the treated pockets to promote healing and tissue regeneration, following the "Clean and Seal" protocol.

Sponsors & Collaborators

  • Marwan El Mobadder

    lead OTHER

Principal Investigators

  • Marwan El Mobadder, Doctor Ph.D · Department of Periodontology, Faculty of dental medicine, Lebanese University

  • Kinga Grzech-Lesiniak, Ph.D (doctor) · Dental Surgery Department, Wroclaw Medical University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
16 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-03-11
Primary Completion
2026-06-30
Completion
2026-08-31

Countries

  • Lebanon

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07474272 on ClinicalTrials.gov