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Periodontal Health and Sodium Bicarbonate Toothpaste

NCT07274189 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 100

Last updated 2025-12-22

No results posted yet for this study

Summary

The goal of this clinical trial is to determine whether sodium bicarbonate fluoride toothpaste can help maintain periodontal health in adults who have undergone non-surgical periodontal treatment. The main question it aims to answer is:

Does daily use of toothpaste affect the following outcomes: clinical oral health (plaque scores, gingival bleeding scores and periodontal pocket depths), salivary biochemical markers and the oral microbiome.

Outcomes measures will be recorded at 0,3, and 6 months, during which time participants will receive either the treatment or placebo toothpaste and undergo oral hygiene instruction and PMPR over 6 months.

Conditions

  • Periodontal Diseases

Interventions

PROCEDURE

Periodontal treatment and OHI

6 months periodontal treatment \& OHI

PROCEDURE

no treatment received

Baseline; 0 months (no periodontal treatment)

PROCEDURE

Periodontal treatment and OHI

3 months periodontal treatment \& OHI

Sponsors & Collaborators

  • HALEON

    collaborator INDUSTRY

  • University of Plymouth

    lead OTHER

Principal Investigators

  • Zoe Brookes, BDS, MJDF, PCHE, SFHEA, PhD · University of Plymouth

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-12-04
Primary Completion
2026-10-20
Completion
2027-01-30

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07274189 on ClinicalTrials.gov