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MULTIMODAL APPROACH IN THE DIAGNOSIS OF SEPTIC AKI

NCT07472452 · Status: NOT_YET_RECRUITING · Type: OBSERVATIONAL · Enrollment: 130

Last updated 2026-03-16

No results posted yet for this study

Summary

In recent studies, it has been reported that the renal resistance index is effective in detecting sepsis-related acute renal failure (SA-AKI) in the early period. Similarly, urinary biomarkers \[TIMP-2\]\*\[IGFBP-7\], released in response to tubular epithelial cell stress, have been reported to indicate the presence of acute renal injury (AKI) early on, before functional loss occurs (increased creatinine). This observational study aims to evaluate the renal resistance index and urinary biomarker variation in patients diagnosed with sepsis and to investigate their usefulness in the early detection of renal dysfunction that may develop after sepsis.

Conditions

Interventions

DIAGNOSTIC_TEST

Renal Resistive Index (RRI) Doppler Ultrasound

Doppler ultrasonography will measure RRI immediately after sepsis diagnosis (T0), at 24 hours (T24), and at 48 hours (T48).

DIAGNOSTIC_TEST

Urinary TIMP-2 and IGFBP-7 biomarkers

Urine samples for \[TIMP-2\]\*\[IGFBP-7\] biomarker measurement will be collected immediately after sepsis diagnosis (T0) and 24 hours later (T24).

Sponsors & Collaborators

  • Ankara Etlik City Hospital

    lead OTHER_GOV

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-03-30
Primary Completion
2026-06-30
Completion
2027-01-30

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Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07472452 on ClinicalTrials.gov