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L-serine and Strength Training in the Elderly

NCT07466290 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 126

Last updated 2026-03-12

No results posted yet for this study

Summary

This study investigates whether taking the amino acid L-serine, either alone or in combination with targeted strength training, can have a positive effect on mental performance, brain function, and physical fitness in older people.

Healthy, independent women and men aged 65 to 85 are eligible to participate. Participants will be randomly assigned to one of three groups: placebo, L-serine, or L-serine combined with strength training.

Cognitive tests, physical performance tests, and blood and brain tests will be conducted over a period of 48 weeks. The aim is to gain a better understanding of how nutrition and exercise can contribute to healthy aging.

Conditions

  • Brain Health
  • Longevity
  • Cognitive Performance
  • Strength Training Effects
  • Healthy Ageing
  • Ageing
  • Cognition
  • Memory
  • Muscle Strength

Interventions

BEHAVIORAL

Strength training

Structured strength training 2x/week

DIETARY_SUPPLEMENT

L-serine supplementation

L-serine supplementation 6g/day

DIETARY_SUPPLEMENT

Control (cornstarch)

Placebo 6g cornstarch/day, No strength training

Sponsors & Collaborators

  • Medical University of Vienna

    collaborator OTHER

  • University of Vienna

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
65 Years
Max Age
85 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-03-31
Primary Completion
2027-12-31
Completion
2028-12-31

Countries

  • Austria

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07466290 on ClinicalTrials.gov