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Outcomes of Health Care Transition for AYA With a Cancer Predisposition

NCT07456904 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 56

Last updated 2026-04-23

No results posted yet for this study

Summary

This observational study evaluates whether adolescents and young adults (AYAs) with a cancer predisposition syndrome (CPS) establish and maintain adult health care and continue CPS-specific cancer surveillance after graduating from pediatric care at St. Jude Children's Research Hospital (SJCRH). Participants will complete a Readiness Assessment and periodic surveys over 8 years post-graduation.

Primary Objectives

* To evaluate whether adolescents and young adults (AYAs) with a cancer predisposition syndrome (CPS) report they have established care with adult health care providers and pursue CPS-specific cancer surveillance within 1-year post-graduation from SJCRH.
* To evaluate whether AYAs with CPS report they maintain care with adult health care providers and continue CPS-specific cancer surveillance 3 years post-graduation from SJCRH.

Exploratory Objectives:

* To evaluate whether AYAs with CPS report they continue to maintain care with adult health care providers and complete CPS-specific cancer surveillance longitudinally 5 years and 8 years post-graduation from St. Jude Children's Research Hospital (SJCRH).
* To examine clinical correlates of establishing care with adult providers and initiating CPS-specific cancer surveillance post-graduation from SJCRH.
* To identify the tumors diagnosed in AYAs with CPS after they graduate from SJCRH and determine how these tumors were identified (i.e., through specific surveillance tests or based on symptoms).
* To identify barriers and facilitators AYAs face when establishing and maintaining adult health care and pursuing CPS-specific cancer surveillance.

Conditions

  • Genetic Predisposition

Interventions

BEHAVIORAL

Readiness Assessment

Electronic assessment administered 1 month post-graduation to evaluate transition preparedness.

BEHAVIORAL

Transition Outcomes Survey A

Administered at 1 and 3 years post-graduation to assess health care engagement and psychosocial outcomes.

BEHAVIORAL

Transition Outcomes Survey B

Administered at 5 and 8 years post-graduation to assess long-term outcomes and cancer surveillance adherence.

Sponsors & Collaborators

Principal Investigators

  • Melissa R Perrino, MD · St. Jude Children's Research Hospital

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-06-30
Primary Completion
2034-11-30
Completion
2037-11-30

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07456904 on ClinicalTrials.gov