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Impact of NR3C1 rs41423247 (BclI) Polymorphism on Disease Severity in Alopecia Areata

NCT07455708 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 120

Last updated 2026-03-06

No results posted yet for this study

Summary

Alopecia areata is an autoimmune, non-scarring hair loss disorder with multifactorial pathogenesis. The glucocorticoid receptor gene (NR3C1) plays an essential role in immune regulation and inflammatory response. The rs41423247 polymorphism (BclI) may influence glucocorticoid sensitivity and disease activity. This study aims to investigate the association between NR3C1 rs41423247 polymorphism and susceptibility to alopecia areata and to evaluate its correlation with disease severity using the Severity of Alopecia Tool (SALT) score.

Conditions

  • Alopecia Areata(AA)

Sponsors & Collaborators

  • Benha University

    lead OTHER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-11-01
Primary Completion
2024-11-01
Completion
2024-12-01

Countries

  • Egypt

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07455708 on ClinicalTrials.gov