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Androgenetic Alopecia and the JAK-STAT Pathway

NCT03694067 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 25

Last updated 2020-01-28

No results posted yet for this study

Summary

It is a well known fact that the JAK-STAT pathway plays a pivotal role in the pathogenesis of alopecia areata. Both phosphorylated STAT 1 and 3 have been found to be upregulated in the disease. However, whether this pathway plays a role in other hair loss disorders remains unclear. The study aims at assessing STAT3 levels in male patients with androgenetic alopecia. The investigators hypothesize that STAT3 levels will be elevated (due to a previous study proving that JAK-STAT pathway is involved in non-immune mediated hair loss in mice.

Conditions

Interventions

OTHER

Punch skin biopsy

One 1 mm punch biopsy will be taken from the patients from balding scalp. Another 1 mm punch biopsy will be taken from an area of occipital non-balding scalp of the same individual. Local anesthesia will be injected around the biopsy site beforehand.

Sponsors & Collaborators

  • Cairo University

    lead OTHER

Principal Investigators

  • Akmal S Hassan, MD · Cairo University

Eligibility

Min Age
18 Years
Sex
MALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-10-15
Primary Completion
2019-12-01
Completion
2019-12-01

Countries

  • Egypt

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03694067 on ClinicalTrials.gov