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Live Birth Rate After First Embryo Transfer With or Without Glucocorticoid Sensitivity Testing

NCT07449494 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 148

Last updated 2026-03-04

No results posted yet for this study

Summary

This retrospective single-center observational cohort study evaluates live birth rates after the first embryo transfer following immune assessment in infertile women with documented uterine immune overactivation.

In routine clinical practice, glucocorticoids represent first-line therapy for immune overactivation. Some patients underwent glucocorticoid sensitivity testing prior to embryo transfer based solely on standard clinical practice and patient preference. In cases of demonstrated glucocorticoid resistance, alternative therapeutic strategies were implemented according to usual care.

The study analyzes clinical data collected between September 2020 and November 2025 to assess the association between prior glucocorticoid sensitivity testing and live birth rate after the first fresh or frozen blastocyst transfer performed following immune evaluation.

No treatment allocation was determined by a study protocol.

Conditions

Sponsors & Collaborators

  • Hopital Pierre Rouques - Les Bluets

    lead OTHER

Eligibility

Max Age
40 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-09-01
Primary Completion
2025-09-17
Completion
2025-09-18

Countries

  • France

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07449494 on ClinicalTrials.gov