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Upper Airway Ultrasound to Predict Difficult Laryngoscopy in Neonates and Infants

NCT07444528 · Status: ENROLLING_BY_INVITATION · Type: OBSERVATIONAL · Enrollment: 180

Last updated 2026-03-04

No results posted yet for this study

Summary

Upper airway ultrasound (UA-US) has been utilized in adults to predict difficult laryngoscopy (Cormick-Lehane view 3 or 4) and difficult tracheal intubation (DTI) (≥3 intubation attempts) and with moderate-to-high sensitivity and specificity. This bedside technique is reproducible, easy-to-do without any additional radiation risk, and was added to the most recent American Society of Anesthesiologists (ASA) Practice Guidelines for Difficult Airway Management in Adults. However, UA-US has only been applied to older children ages 5-12 and has not been examined in neonates and infants. Thus, the aim of this observational study using UA-US to predict difficult laryngoscopy and tracheal intubation in neonates and infants presenting for diagnostic, procedural or surgical care under general anesthesia requiring endotracheal intubation.

Conditions

  • Neonates
  • Infants Aged 0 Days to 12 Months Scheduled for Elective Surgery

Interventions

OTHER

Upper airway ultrasound

The investigator will perform 6 UA-US measurements will be obtained with a high frequency linear array or curvilinear US probe following induction of anesthesia but prior to laryngoscopy or TI: distance from the skin to the epiglottis, distance from the skin to the hyoid bone, distance from skin to vocal cords, hyomental distance, tongue thickness, and tongue cross-sectional area.

Sponsors & Collaborators

Principal Investigators

  • Elizabeth M O'Brien, MD, MAS · Children's Hospital of Philadelphia

Eligibility

Max Age
365 Days
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-03-02
Primary Completion
2027-12-31
Completion
2027-12-31

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07444528 on ClinicalTrials.gov