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Acute Muscle Damage After Eccentric Quasi-Isometric Exercise of the Elbow Flexors

NCT07431879 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 30

Last updated 2026-02-25

No results posted yet for this study

Summary

This study compared the acute muscle damage responses of the elbow flexor muscles following two types of resistance exercise: eccentric quasi-isometric (EQI) exercise and traditional eccentric (ECC) exercise. Thirty healthy young men were randomly assigned to perform either EQI or ECC using a dumbbell elbow flexion exercise. Both groups exercised with the same relative external load and performed the exercise to voluntary fatigue.

Muscle function, muscle soreness, and blood markers related to muscle damage were assessed before exercise, immediately after exercise, and over a 7-day recovery period. The purpose of this study was to examine whether EQI exercise, which involves a prolonged isometric phase followed by a very slow eccentric action, induces different levels of acute muscle damage and recovery compared with traditional eccentric exercise.

Conditions

  • Acute Muscle Damage Following Resistance Exercise

Interventions

BEHAVIORAL

Eccentric Quasi-Isometric Exercise

Eccentric quasi-isometric (EQI) exercise of the elbow flexors was performed using a unilateral dumbbell preacher curl. The external load was set at 70% of each participant's one-repetition maximum. Each repetition began with a sustained isometric contraction at 90 degrees of elbow flexion until task failure, followed immediately by a very slow eccentric lengthening to full elbow extension while participants continued to resist the load. One repetition was defined as the continuous task from the onset of the isometric hold to full elbow extension. Participants completed five sets of one repetition with 90 seconds of rest between sets. All repetitions were performed to voluntary fatigue under supervision.

BEHAVIORAL

Traditional Eccentric Exercise

Traditional eccentric-only exercise of the elbow flexors was performed using a unilateral dumbbell preacher curl. The external load was set at 70% of each participant's one-repetition maximum. From a starting position of 90 degrees of elbow flexion, participants repeatedly lowered the dumbbell through the full range of motion using controlled eccentric contractions at a cadence of approximately 2.5 seconds per repetition, guided by a metronome. Each set was performed to voluntary failure, and a total of five sets were completed with 90 seconds of rest between sets.

Sponsors & Collaborators

  • Chinese Culture University

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
20 Years
Max Age
30 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2020-08-01
Primary Completion
2021-08-01
Completion
2021-08-01

Countries

  • Taiwan

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07431879 on ClinicalTrials.gov