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Post-Operative Pain Relief: Zynrelef or Periarticular Injections in RATKA

NCT07430085 · Status: NOT_YET_RECRUITING · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 150

Last updated 2026-02-27

No results posted yet for this study

Summary

Prospective Cohort of patients who are scheduled for a Robot Assisted Total Knee Arthroplasty (RATKA). A prospective survey of patient reported outcome measures (Numeric Rating Scale) will be obtained postoperatively of 72 hours, as well as at the postoperative opioid consumption after 72 hours.

Conditions

  • Periarticular Block
  • Osteoarthritis (OA)
  • Osteoarthritis (OA) of the Knee
  • Pain After Surgery
  • Knee Arthroplasty, Total

Interventions

COMBINATION_PRODUCT

bupivacaine-meloxicam (extended release)

These surgeons will be using Zynrelef (bupivacaine-meloxicam extended release) as a form of periarticular analgesia.

DRUG

Bupivacaine

These surgeons will be using the control injection (bupivacaine + ketorolac + lidocaine) as a form of periarticular analgesia.

DRUG

Ketorolac

These surgeons will be using the control injection (bupivacaine + ketorolac + lidocaine) as a form of periarticular analgesia.

DRUG

Lidocaine (drug)

These surgeons will be using the control injection (bupivacaine + ketorolac + lidocaine) as a form of periarticular analgesia.

Sponsors & Collaborators

  • Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)

    lead OTHER

Principal Investigators

  • Andrew Waligora, MD · Allegheny Health Network

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
89 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-01-31
Primary Completion
2028-01-31
Completion
2028-02-28
FDA Drug
Yes

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07430085 on ClinicalTrials.gov