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Multicenter Study of Transcranial Magnetic Stimulation on Vision Restoration

NCT07425717 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 136

Last updated 2026-02-23

No results posted yet for this study

Summary

The goal of this clinical trial is to learn if transcranial magnetic stimulation (TMS) works to restore vision in adults with severe retinal degeneration. It will also learn about the safety of TMS treatment. The main questions it aims to answer are:

1. Does TMS treatment improve the visual function of participants?
2. What medical problems do participants have when receiving TMS treatment? Researchers will compare TMS treatment to a sham stimulation (identical procedures using a sham coil without effective magnetic field output) to see if TMS treatment works to restore their vision.

Participants will:

UndergoTMS treatment to a sham stimulation for consecutive 5 days Visit the clinic at 5 days, 4 weeks, 3 months, 6 months, 12 months after start of the treatment for checkups and tests

Conditions

  • Retinal Degeneration
  • Vision Impairment and Blindness

Interventions

PROCEDURE

Transcranial magnetic stimulation targeting occipital visual cortex

Transcranial magnetic stimulation targeting occipital visual cortex

PROCEDURE

Sham stimulation

identical procedure using a sham coil without effective magnetic field output

Sponsors & Collaborators

  • Shanghai High Myopia Study Group

    lead OTHER

Principal Investigators

  • Xiangjia Zhu, PhD, MD · Eye and Ear, Nose, Throat Hospital of Fudan University

  • Mingguang He · The Hong Kong Polytechnic University

  • Rong Wu · Huadong Hospital of Fudan University

  • Bo Ma · Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
45 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-06-01
Primary Completion
2028-05-31
Completion
2029-05-31

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07425717 on ClinicalTrials.gov