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Evaluation of a Stannous Fluoride Dentifrice for Control of Oral Malodor

NCT07425509 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 49

Last updated 2026-02-23

No results posted yet for this study

Summary

This single-center, randomized, double-blind, two-treatment crossover clinical study evaluated the safety and efficacy of a stannous fluoride-containing dentifrice compared with a sodium fluoride control dentifrice for the control of intrinsic oral malodor. Adult subjects brushed twice daily with each product during separate treatment periods following standardized wash-out periods. Oral malodor was assessed using trained organoleptic judges applying a validated Odor Intensity (OI) scale at baseline and multiple post-treatment time points.

Conditions

  • Oral Malodor (Halitosis)

Interventions

DRUG

Sodium Fluoride Dentifrice

Comparator toothpaste (0.243% NaF)

DRUG

Stannous Fluoride Toothpaste (SnF)

Test toothpaste (0.454% SnF)

Sponsors & Collaborators

  • Church & Dwight Company, Inc.

    lead INDUSTRY

Principal Investigators

  • Annahita Ghassemi, PhD · Church & Dwight, Inc.

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2024-09-09
Primary Completion
2024-11-04
Completion
2024-11-04

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07425509 on ClinicalTrials.gov