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Entropy-based Physiological Signal Analysis in Patients With Obstructive Sleep Apnoea

NCT07406620 · Status: NOT_YET_RECRUITING · Type: OBSERVATIONAL · Enrollment: 160

Last updated 2026-02-12

No results posted yet for this study

Summary

This observational study is being undertaken as a part of a Master of Research (MRes) in Clinical Research programme.

Its goal is to learn about how continuous positive airway pressure (CPAP) therapy changes the complexity of body signals in adults with obstructive sleep apnoea (OSA). The main question it aims to answer is:

\- How does the complexity of physiological signals (specifically oxygen saturation, heart rate variability, and airflow) change in adults with OSA from before to after three and six months of CPAP treatment?

It will use data from individuals who took part in an earlier trial, called 3DPiPPIn, which tested the use of 3D-printed, customised masks CPAP masks through sleep studies.

Conditions

  • Obstructive Sleep Apnoea (OSA)

Interventions

DEVICE

Continuous Positive Airway Pressure Therapy

The intervention of interest within this secondary analysis study is Continuous Positive Airway Pressure (CPAP) Therapy, a device-based treatment used to maintain airway patency in patients with sleep-disordered breathing. As a retrospective study, participant exposure to CPAP occured exclusively within the original 3DPiPPIn trial.

Sponsors & Collaborators

Principal Investigators

  • Izaak Neri · King's College London

  • Stephanie K Mansell · Royal Free London NHS Foundation Trust, University College London

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-04-30
Primary Completion
2026-07-31
Completion
2026-09-30

Countries

  • United Kingdom

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07406620 on ClinicalTrials.gov