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Musculoskeletal Outcomes Using Tylenol/Ibuprofen vs. Oral Steroids in New Injuries

NCT07393503 · Status: ENROLLING_BY_INVITATION · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 60

Last updated 2026-02-18

No results posted yet for this study

Summary

In this pilot study, the investigators aim to compare two short-term pain relief methods administered over the course of 6 days in the setting of acute musculoskeletal (MSK) pain:

1. Methylprednisolone((Medrol)dose pack- standard taper per dose pack instructions
2. Standard of Care (SOC) which includes a combination of Acetaminophen (Tylenol)+Ibuprofen (Motrin)

The investigators are interested in studying pain relief regimens for acute injury of any body part among an adult orthopaedic urgent care population.

Conditions

Interventions

DRUG

Methylprednisolone 4Mg Tab

Participants follow standard 6- day taper dosing schedule.

DRUG

Acetaminophen 500Mg Tab

Participants follow a 6- day taper dosing schedule.

DRUG

Ibuprofen 200Mg Oral Tablet

Participants follow a 6- day taper dosing schedule.

Sponsors & Collaborators

  • State University of New York at Buffalo

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
SINGLE
Model
SEQUENTIAL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-09-17
Primary Completion
2026-08-31
Completion
2027-01-31
FDA Drug
Yes

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07393503 on ClinicalTrials.gov