The FDA approved Tecvayli plus Darzalex Faspro for relapsed or refractory multiple myeloma after at least one prior therapy, and accepted a new drug application for iberdomide plus daratumumab and dexamethasone with a PDUFA date of August 17, 2026.
The FDA approved Tecvayli plus Darzalex Faspro for relapsed/refractory multiple myeloma in March 2026, and Darzalex Faspro-based quadruplet D-VRd for newly diagnosed transplant-ineligible patients in January 2026.
The FDA approved the combination of acalabrutinib and venetoclax as the first all-oral, fixed-duration regimen for adults with previously untreated chronic lymphocytic leukemia or small lymphocytic lymphoma, based on Phase 3 AMPLIFY trial results.
The FDA has approved a supplemental new drug application for the combination regimen of Venclexta (venetoclax) and acalabrutinib for previously untreated adult patients with chronic lymphocytic leukemia, supported by Phase 3 AMPLIFY trial data.
The FDA approved acalabrutinib plus venetoclax as the first all-oral, fixed-duration regimen for previously untreated chronic lymphocytic leukemia, based on phase III AMPLIFY trial results showing 35% reduction in disease progression or death risk versus chemoimmunotherapy.
The FDA has approved the combination of Venclexta (venetoclax) plus acalabrutinib as the first all-oral, fixed-duration regimen for previously untreated adults with chronic lymphocytic leukemia, based on Phase III AMPLIFY study results.
The FDA approved multiple denosumab biosimilars in late 2025 and issued REMS safety updates emphasizing severe hypocalcemia risk in patients with advanced chronic kidney disease, including reported hospitalizations and fatalities.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07602595 |
The BRIDGE Pain Study |
RECRUITING | |
| NCT07602426 |
A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Effects of resO™ Bone and Joint Support Postbiotic on Physical Function, Pain Interference, and Mobility in Adults With Joint Discomfort |
ACTIVE_NOT_RECRUITING | NA |
| NCT07585292 |
Transcutaneous Auricular Vagus Nerve Stimulation as a Treatment for Musculoskeletal Pain in Cerebral Palsy |
NOT_YET_RECRUITING | NA |
| NCT07571967 |
AI-Assisted Camera-Based Progressive Muscle Relaxation for Office Workers |
COMPLETED | NA |
| NCT07554664 |
Central Sensitization, Work-Related Stress, and Musculoskeletal Symptoms in Desk-Based Workers With and Without Migraine |
RECRUITING | |
| NCT07504094 |
Active Coping: Interdisciplinary Program for Chronic Pain, Physiotherapy Unit (Spain) |
NOT_YET_RECRUITING | NA |
| NCT07501273 |
Analgesic Effect of a Biophotonic Foot Massage Cream |
NOT_YET_RECRUITING | NA |
| NCT07498491 |
Weighted Blanket Use for Adults With Chronic Pain |
NOT_YET_RECRUITING | NA |
| NCT07456150 |
Personalizing Veteran Pain Care: Adapting Coaching Interventions to Support Maintenance of Self-Care |
NOT_YET_RECRUITING | PHASE1 |
| NCT07451587 |
Personalized Care Management Model (GAP-421) for Chronic Pain in Primary Care Physiotherapy |
NOT_YET_RECRUITING | NA |
